Reversal of cognitive decline: A novel therapeutic program, by Dale Bredesen

This months Living Beyond Dementia™ blog (yes, only one again as I am too busy living beyond dementia), is on the following study (Abstract and Summary only included – follow the link to the full study),

Reversal of cognitive decline: A novel therapeutic program

Dale E. Bredesen1, 2
1 Mary S. Easton Center for Alzheimer’s Disease Research, Department of Neurology, University of California, Los Angeles, CA 90095;
2 Buck Institute for Research on Aging, Novato, CA 94945.

Abstract

This report describes a novel, comprehensive, and personalized therapeutic program that is based on the underlying pathogenesis of Alzheimer’s disease, and which involves multiple modalities designed to achieve metabolic enhancement for neurodegeneration (MEND). The first 10 patients who have utilized this program include patients with memory loss associated with Alzheimer’s disease (AD), amnestic mild cognitive impairment (aMCI), or subjective cognitive impairment (SCI). Nine of the 10 displayed subjective or objective improvement in cognition beginning within 3-6 months, with the one failure being a patient with very late stage AD. Six of the patients had had to discontinue working or were struggling with their jobs at the time of presentation, and all were able to return to work or continue working with improved performance. Improvements have been sustained, and at this time the longest patient follow-up is two and one-half years from initial treatment, with sustained and marked improvement. These results suggest that a larger, more extensive trial of this therapeutic program is warranted. The results also suggest that, at least early in the course, cognitive decline may be driven in large part by metabolic processes. Furthermore, given the failure of monotherapeutics in AD to date, the results raise the possibility that such a therapeutic system may be useful as a platform on which drugs that would fail as monotherapeutics may succeed as key components of a therapeutic system.

In summary:

•A novel, comprehensive, and personalized therapeutic system is described that is based on the underlying pathogenesis of Alzheimer’s disease. The basic tenets for the development of this system are also described.

•Of the first 10 patients who utilized this program, including patients with memory loss associated with Alzheimer’s disease (AD), amnestic mild cognitive impairment (aMCI), or subjective cognitive impairment (SCI), nine showed subjective or objective improvement.

•One potentially important outcome is that all six of the patients whose cognitive decline had a major impact on job performance were able to return to work or continue working without difficulty.

•These anecdotal results suggest the need for a controlled clinical trial of the therapeutic program.

Blog author’s comment: 

What I believe this study indicates is that further studies are warranted to support this anecdotal evidence, and it is excellent to report that is in progress. Whilst this is a very small sample, in view of the fact that until now no cases of reversal have ever been documented by an expert it adds weight to the findings.

People with dementia deserve better, and for these types of studies to be expanded, and I have heard very recently (via a colleague) that Dr Bredesen and his new CEO Thom Mount report a 90% success in 112 patients and that there are soon to be new trials at Oxford and the Cleveland Clinic.

 


7 thoughts on “Reversal of cognitive decline: A novel therapeutic program, by Dale Bredesen

  1. Reblogged this on memory issues and commented:
    It’s a shame Australia is so far away or we’d be on our way ASAP. How fantastic that there are approaches to arresting cognitive decline that don’t involve taking medication that often has a Black Box warning.

    Like

    1. Please feel free to. The more we can support people to improve, or perhaps not even get dementia at all, obviously the better. It seems the drug companies are not so keen on it though…

      Like

  2. Reblogged this on zuzusays and commented:
    This study looks like they are finally putting together several ideas that improve physical health lifestyle ideas that may improve cognitive function. We all hear about how diet, exercise, vitamins and minerals, supplements affect physical and mental function. I’m glad they are finally testing these ideas to see if there’s real improvement and for which types of dementia.

    Like

    1. Most of the things are hat I have been doing, since about a year after diagnosis, so I am definitely a good case of anecdotal evidence it works! Thankfully I ignored the health sector…

      Like

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